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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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CBP-mediated post-translational N-glycosylation of BRCA2

Habibur Siddique1, Veena N Rao, E Shyam P Reddy

  • 1Cancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.

International Journal of Oncology
|July 7, 2009
PubMed

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Targeting proteins to the ER
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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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Covalently Linked Protein Regulators

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Base Excision Repair

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The first step of...
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Regulation of Nuclear Protein Sorting

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