Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow transplant retinopathy.

P F Lopez1, P Sternberg, C K Dabbs

  • 1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

American Journal of Ophthalmology
|December 25, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adverse pregnancy outcomes and subsequent development of connective tissue disease in the UK: an epidemiological study.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

SU-E-T-429: Image-Guided Eye Plaque Brachytherapy Optimization: Implications for Patients at 2-Year Follow-up.

Medical physics·2017
Same author

SU-E-J-189: The Kullback-Leiber Divergence for Quantifying Changes in Radiotherapy Treatment Response.

Medical physics·2017
Same author

SU-E-J-191: A Multivariate Framework for N-Tissue Classification in Treatment Assessment of Glioblastomas.

Medical physics·2017
Same author

Gene Ontology annotations and resources.

Nucleic acids research·2012
Same author

Heme synthesis in pyridoxine-responsive anemia.

The New England journal of medicine·2011
Same journal

Performance of the ISOLD Score (Interleukin Score for IntraOcular Lymphoma Diagnosis) in the Diagnosis of Vitreoretinal Lymphoma in Clinical Practice.

American journal of ophthalmology·2026
Same journal

Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

American journal of ophthalmology·2026
Same journal

Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

American journal of ophthalmology·2026
Same journal

Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

American journal of ophthalmology·2026
See all related articles

High-dose chemotherapy may increase the risk of retinopathy after bone marrow transplants. Patients receiving chemotherapy and radiation developed occlusive microvascular retinopathy, including macular edema.

Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Bone marrow transplantation (BMT) is a critical treatment for acute leukemia.
  • Survivors of BMT may experience long-term complications.
  • Ocular complications, particularly retinopathy, are a concern after BMT.

Purpose of the Study:

  • To investigate the incidence and characteristics of retinopathy in acute leukemia patients post-BMT.
  • To assess the potential role of high-dose chemotherapy and radiation in developing retinopathy.

Main Methods:

  • Retrospective analysis of eight patients with acute leukemia undergoing autologous or allogeneic BMT.
  • Evaluation of patients surviving at least six months post-transplant for ocular complications.
  • Review of BMT protocols, including chemotherapy agents and radiation doses.

Related Experiment Videos

Main Results:

  • Five of eight (62%) surviving patients developed occlusive microvascular retinopathy.
  • Clinically significant macular edema occurred in 80% of affected patients.
  • One case of proliferative retinopathy with subhyaloid hemorrhage was observed.

Conclusions:

  • High-dose cytarabine hydrochloride combined with total body irradiation (1,200 cGy) is associated with a high incidence of retinopathy.
  • Low-dose radiation therapy may contribute to retinopathy development when administered with high-dose chemotherapy.
  • Chemotherapy may potentiate radiation-induced retinopathy, suggesting a need for dose-adjustment considerations.