Related Experiment Video

Updated: Jun 21, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
06:04

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Published on: September 2, 2020

TRP channel antagonists for pain--opportunities beyond TRPV1

Stuart Bevan1, David A Andersson

  • 1Wolfson Centre for Age Related Diseases, King's College London, Wolfson Wing, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK. stuart.bevan@kcl.ac.uk

Current Opinion in Investigational Drugs (London, England : 2000)
|July 7, 2009
PubMed

Insights

Transient receptor potential (TRP) channels in sensory neurons are key to signal transduction. Research suggests TRP channel blockers may effectively treat acute and chronic pain.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Transient receptor potential (TRP) ion channels are expressed in sensory neurons.
  • These channels are crucial for transducing chemical, thermal, and mechanical signals.
  • Growing interest in TRP channels' role in pain pathways.

Purpose of the Study:

  • To investigate the role of sensory TRP channels in acute and chronic pain.
  • To explore the therapeutic potential of targeting TRP channels for pain management.

Main Methods:

  • Utilizing RNAi techniques to reduce TRP channel expression.
  • Employing genetically modified mice lacking specific TRP channels.
  • Conducting pharmacological studies with novel investigational compounds.

Main Results:

  • TRP channels are implicated in the transduction of various sensory signals.
  • Evidence suggests specific TRP channels (TRPA1, TRPM8, TRPV4, TRPV3) are involved in pain.
  • Investigational compounds targeting these channels show promise.

Conclusions:

  • TRP channels are significant players in pain signaling.
  • Pharmacological inhibition of TRPA1, TRPM8, TRPV4, or TRPV3 channels may offer new pain treatments.
  • Further research into TRP channel modulators is warranted for pain therapy.

More Related Videos

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 109:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.