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Sequential transmission and long-term persistence of an HIV strain partially resistant to protease inhibitors

Ennio Polilli1, Francesco Di Masi, Federica Sozio

  • 1Clinical Pathology Unit, "Spirito Santo" Hospital, Pescara, Italy.

The New Microbiologica
|July 8, 2009
PubMed

Insights

Secondary transmission of drug-resistant HIV-1 occurred, involving a protease inhibitor (PI) mutation. This specific PI mutation was detected in both partners and persisted in the female partner for over a year.

Area of Science:

  • Virology
  • Infectious Diseases
  • Genetics

Background:

  • Drug-resistant human immunodeficiency virus type 1 (HIV-1) transmission is a growing concern.
  • Commonly observed resistance mutations include thymidine analogue mutations and non-nucleoside reverse transcriptase inhibitor mutations.

Observation:

  • A case of secondary transmission of a primary protease inhibitor (PI) mutation is reported.
  • The mutation was transmitted from an untreated infected male subject to his sexual partner.

Findings:

  • Sequences from both patients exhibited high identity (>99%).
  • Both individuals carried the major IAS PI mutation M46I.
  • The M46I mutation remained detectable in the female partner's bloodstream for one year post-detection.

Implications:

  • This case highlights the potential for transmission of specific PI resistance mutations.
  • Understanding transmission dynamics of drug-resistant HIV-1 is crucial for treatment and prevention strategies.
  • The persistence of the mutation suggests long-term implications for treatment efficacy in the transmitted partner.

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