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Related Experiment Videos

Delayed-type hypersensitivity and circulating basophils. A population study.

M Chavance1, B Herbeth, B Lesourd

  • 1INSERM U169, Villejuif, France.

Allergy
|August 1, 1991
PubMed
Summary
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Higher percentages of basophils correlate with more positive delayed-type hypersensitivity (DTH) responses in older adults. This suggests basophils may play a role in the initial stages of DTH immune reactions.

Area of Science:

  • Immunology
  • Gerontology

Background:

  • Delayed-type hypersensitivity (DTH) is a critical immune response.
  • Understanding factors influencing DTH in the elderly is important for health assessments.

Purpose of the Study:

  • To investigate factors associated with DTH in elderly populations.
  • To explore the relationship between basophil levels and DTH response magnitude.

Main Methods:

  • Two groups of elderly subjects (non-hospitalized and hospitalized) were studied.
  • Delayed-type hypersensitivity was assessed using common antigens.
  • The percentage of basophils was correlated with the number and diameter of positive DTH responses.

Main Results:

  • Percent basophils showed a consistent positive correlation with the number of positive DTH responses across different samples.

Related Experiment Videos

  • Higher basophil percentages were associated with a greater number of positive DTH responses, even after adjusting for age, sex, and sample.
  • No significant relationship was found between basophil percentage and the diameter of DTH reactions.

    • Conclusions:

    • Basophil levels appear to be linked to the number of positive DTH responses in the elderly.
    • The findings suggest basophils may be involved in the early, rather than the later, phases of DTH.
    • Immune response patterns, including DTH, vary with age and sex in older individuals.