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Updated: Jun 21, 2026

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Published on: February 16, 2024

Priapism associated with olanzapine.

S H Hosseini¹, A K Polonowita

¹Department of Psychiatry, Behavioral Science and Psychiatric Research Center, Zare Psychiatry Hospital, Mazandaran Medical Sciences University, K.M5 Sari-Neka High Way, Sari, Mazandaran, Post Cod 48171-19164, Iran.

Pakistan Journal of Biological Sciences : PJBS

|July 8, 2009

Summary

This summary is machine-generated.

Priapism, a rare side effect of psychotropic drugs, can be linked to antipsychotics like olanzapine. Careful prescription of Serotonin-Dopamine Antagonists is advised, especially for patients with a history of drug-induced priapism.

Related Experiment Videos

Last Updated: Jun 21, 2026

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Published on: February 16, 2024

Area of Science:

Psychiatry
Pharmacology
Urology

Background:

Priapism is a rare but serious adverse effect of psychotropic medications.
Antipsychotic agents are implicated in 15-26% of medication-associated priapism cases.
Atypical antipsychotics such as clozapine, risperidone, and olanzapine have been linked to priapism.

Observation:

A 24-year-old male presented with delusions and hallucinations, diagnosed with a psychiatric disorder.
The patient developed priapism after initiating olanzapine treatment.
This case highlights a specific instance of olanzapine-induced priapism.

Findings:

Olanzapine, an atypical antipsychotic and a Serotonin-Dopamine Antagonist (SDA), was associated with priapism in this patient.
The patient's psychiatric symptoms included delusions of control, persecution, somatic delusions, and auditory hallucinations.
The onset of priapism occurred during the course of olanzapine treatment.

Implications:

Serotonin-Dopamine Antagonists (SDAs) should be prescribed with caution due to the risk of priapism.
Patients with a prior history of priapism, particularly following psychotropic drug use, require careful monitoring.
This case underscores the importance of recognizing and managing rare but severe adverse drug reactions in psychiatric practice.