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Published on: January 18, 2019

[Serum adiponectin and resistin level in children with idiopathic nephrotic syndrome]

Anna Medyńska1, Katarzyna Kiliś-Pstrusińska, Anna Galar

  • 1Department of Pediatric Nephrology of Medical University of Wroclaw.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|July 8, 2009
PubMed

Insights

Children with idiopathic nephrotic syndrome (INS) show elevated serum resistin and adiponectin levels, suggesting these adipokines may influence the disease. Further research is needed to confirm their role in INS pathogenesis.

Area of Science:

  • Endocrinology
  • Pediatric Nephrology
  • Immunology

Context:

  • Adipose tissue functions as an endocrine organ, releasing adipokines.
  • Adipokines play a role in modulating inflammatory responses.
  • Idiopathic nephrotic syndrome (INS) is a kidney disorder primarily affecting children.

Purpose:

  • To evaluate serum resistin and adiponectin levels in children diagnosed with idiopathic nephrotic syndrome (INS).

Summary:

  • Serum resistin and adiponectin levels were significantly increased in children with INS (both relapse and remission) compared to healthy controls.
  • While resistin levels trended lower in remission, no statistically significant difference was found between relapse and remission phases.
  • Positive correlations were observed between resistin and cholesterol/proteinuria, and a negative correlation with serum albumin.

Impact:

  • Findings suggest that elevated resistin and adiponectin may be involved in the pathogenesis of childhood INS.
  • These results highlight potential biomarkers for INS and warrant further investigation in larger cohorts.
  • Understanding the role of adipokines in INS could lead to novel therapeutic strategies.
Abstract

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