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Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Updated: Jun 21, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

[Bone metastases pain in the elderly].

K Chouahnia1, M Luu, N Baba-Hamed

  • 1Service d'oncologie médicale, Hôpital Avicenne, 125, rue de Stalingrad, 93009 Bobigny cedex, France.

Revue Medicale Suisse
|July 8, 2009
PubMed
Summary

Cancer pain, especially from bone metastases in older adults, significantly impacts quality of life. Early assessment and diverse treatments are crucial for managing this common and severe symptom in elderly cancer patients.

Area of Science:

  • Oncology
  • Geriatrics
  • Palliative Care

Context:

  • Over 60% of new cancer cases in Europe and the US are diagnosed in individuals over 65.
  • Cancer pain, particularly from bone metastases, is a prevalent and severe issue in elderly patients, often with multiple comorbidities.
  • Bone metastases are the third most common type of metastasis, frequently associated with breast, kidney, and prostate cancers.

Purpose:

  • To highlight the significant impact of cancer-related pain, especially bone metastases, on the quality of life in elderly patients.
  • To underscore the prevalence of pain at different stages of cancer diagnosis and advanced disease.
  • To outline the available therapeutic strategies for managing bone metastases pain.

Summary:

  • Cancer pain, a major symptom, is particularly debilitating in elderly patients with bone metastases, affecting autonomy and quality of life.

Related Experiment Videos

Last Updated: Jun 21, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

  • Pain is present at diagnosis in one-third of cases and in two-thirds of advanced disease cases.
  • Treatment options include chemotherapy, surgery, radiotherapy, bisphosphonates, and analgesic therapies.

    • Impact:

    • Improved understanding of the burden of bone metastases pain in the elderly population.
    • Emphasis on the need for validated tools for pain assessment in this demographic.
    • Informed clinical decision-making regarding multimodal treatment approaches for cancer pain management.