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Updated: Jun 21, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Central nervous system is a sanctuary site for chronic myelogenous leukaemia treated with imatinib mesylate
Y Isobe1, K Sugimoto, A Masuda
1Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan. yisobe@med.juntendo.ac.jp
Abstract:
Imatinib mesylate (IM) is currently used as the first therapeutic choice against chronic myelogenous leukaemia (CML). Because IM poorly penetrates the blood-brain barrier, IM-treated CML patients may have a potential risk of central nervous system (CNS) involvement. Here we report a case with lymphoid blast crisis isolated only in CNS after bacterial meningitis, although the patient achieved and maintained complete cytogenetic response by IM therapy. It is important to consider isolated CNS blast crisis as a possible event in IM-treated CML patients.
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