Related Experiment Videos
Hypercalcaemia caused by a carcinoid tumour
M M Brzozowska1, L Wolmarans, J V Conaglen
1Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand. mbrzozowska@hotmail.com
Abstract:
Humoral hypercalcaemia resulting from carcinoid tumours is uncommon. We report a case of hypercalcaemia because of excessive secretion of parathyroid hormone-related protein (PTHrP) in a 77-year-old woman with an advanced carcinoid tumour. Fibroblast growth factor 23 levels were also elevated. The hypercalcaemia responded to adjunctive therapy with long-acting octreotide analogue therapy, bisphosphonates and steroids. The role of PTHrP in humoral hypercalcaemia of malignancy, its association with neuroendocrine tumours, as well as the therapeutic use of somatostatin analogues are reviewed.
Related Concept Videos
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Cushing Syndrome I: Introduction
Hyperthyroidism I: Introduction
Skeleton and Calcium Homeostasis
Gastritis II: Pathophysiology
Cushing Syndrome II: Pathophysiology