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Type II transmembrane serine proteases in cancer and viral infections

So-Young Choi1, Stephanie Bertram, Ilona Glowacka

  • 1Omics Fusion Research Center, KRIBB, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Korea.

Trends in Molecular Medicine
|July 8, 2009
PubMed

Insights

Type II transmembrane serine proteases (TTSPs) regulate cell interactions. Aberrant TTSP activity drives cancer and aids viral spread, presenting therapeutic targets for both diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Regulated proteolysis is crucial for tissue development and homeostasis.
  • Uncontrolled proteolytic activity is associated with various diseases.
  • Type II transmembrane serine proteases (TTSPs) are cell-surface enzymes regulating cell-cell and cell-matrix interactions.

Purpose of the Study:

  • To review the role of TTSPs in tumorigenesis.
  • To review the role of TTSPs in viral infections.
  • To discuss potential therapeutic strategies targeting TTSPs.

Main Methods:

  • Literature review of studies on TTSPs in cancer and viral infections.
  • Analysis of molecular mechanisms underlying TTSP function.
  • Synthesis of current research on TTSP-targeted therapies.

Main Results:

  • Aberrant TTSP expression is a hallmark of several cancers.
  • Specific molecular mechanisms link TTSPs to carcinogenesis.
  • Respiratory viruses, including influenza, may utilize TTSPs for propagation.

Conclusions:

  • TTSPs are implicated in both cancer development and viral pathogenesis.
  • Targeting TTSPs offers potential therapeutic avenues for cancer and viral infections.
  • Further research is warranted to develop effective TTSP-based interventions.

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