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Updated: Aug 9, 2026
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Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
[Immunotherapy using high concentration purified antigen showed remarkable effect in all cases]
T Jyo1, M Kuwabara, Y Kodomari
1Department of Internal Medicine, Hiroshima Prefectural Hospital.
Arerugi = [Allergy]
|September 1, 1991
Summary
Hoya (sea-squirt) asthma immunotherapy using purified sea-squirt antigen Ei-M showed rapid, remarkable effects in 21 of 22 patients. Treated individuals could resume oyster shucking work without asthmatic attacks or side effects.
Area of Science:
- Immunology
- Occupational Health
- Allergology
Context:
- Hoya (sea-squirt) asthma is a type I occupational asthma.
- Occupational exposure to sea-squirt antigens can trigger asthma in seafood industry workers.
Purpose:
- To evaluate the efficacy and safety of immunotherapy with purified sea-squirt antigen (Ei-M) for Hoya (sea-squirt) asthma.
Summary:
- Twenty-two female patients with Hoya asthma received two years of immunotherapy with high-concentration purified sea-squirt antigen (Ei-M).
- Twenty-one patients showed remarkable improvement, enabling them to work without asthmatic attacks or need for symptomatic therapy.
- Serum anti-Ei-M IgG antibody levels significantly increased post-therapy, with no reported side effects.
Impact:
- Immunotherapy with Ei-M offers a potentially effective and safe treatment for Hoya (sea-squirt) asthma.
- This treatment allows affected individuals to return to occupational activities without symptom exacerbation.
- The study highlights the potential for targeted antigen immunotherapy in managing occupational asthma.
