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Updated: Jun 21, 2026

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
Published on: June 13, 2010
Detection of fluorescent-labeled probes at subpicomolar concentrations by magnetic modulation
Amos Danielli1, Ady Arie, Noga Porat
1Department of Physical Electronics, Faculty of Engineering, Tel-Aviv University, Tel-Aviv, Israel. amosd@post.tau.ac.il
Abstract:
A sensitive and rapid method for detecting fluorescent dyes at low concentrations in homogenous solution is experimentally demonstrated. Fluorescent-labeled DNA probes are detected by attaching magnetic beads and applying alternating magnetic field gradient. This condenses the fluorescent probes into a small detection volume and eliminates the scattering noise from solution by synchronous detection. For DNA probes concentration of 1 x 10(-13) M the detection signal was 3.3 times higher than the noise, thereby implying detection sensitivity of 3 x 10(-14) M.
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