Postpericardial injury syndrome: an autoimmune phenomenon

Postpericardial injury syndrome (PPIS) is defined as pericarditis or pericardial effusion that results from recent or earlier injury of the pericardium. The clinical features of this syndrome include fever, leukocytosis, and elevated erythrocyte sedimentation rate. Recent studies have established a connection between this clinical presentation and an underlying autoimmune process. The role of the humoral immune response is well established regarding the pathogenesis of PPIS with elevated titers of different antibodies and immune complexes in the circulation correlating with disease activity. Nevertheless, cell-mediated response by different subgroups of T lymphocyte has a significant importance with direct infiltration of pericardial tissue and fluids. The diagnosis of PPIS is still challenging. A strong connection between specific serological immunological markers and the disease would be of great value in diagnosis and treatment.