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[Functional MRI of transplanted kidneys using diffusion-weighted imaging].

D Blondin¹, R S Lanzman, C Mathys

¹Institut für Radiologie, Uniklinikum Düsseldorf, Germany. blondin@med.uni-duesseldorf.de

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin

|July 8, 2009

Summary

Diffusion-weighted imaging (DWI) offers a viable, unenhanced method for assessing renal allografts. Monoexponential apparent diffusion coefficient (ADC) values correlate with renal function, aiding in clinical evaluation.

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Area of Science:

Radiology
Nephrology
Medical Imaging

Context:

Contrast-enhanced MRI is contraindicated in renal allograft recipients due to nephrogenic systemic fibrosis (NSF) risk.
Diffusion-weighted imaging (DWI) presents an alternative for evaluating renal allografts without contrast agents.

Purpose:

To assess the clinical utility of mono- and biexponential analysis of DWI in renal allograft recipients.
To determine if DWI can differentiate between stable and deteriorating allograft function.

Summary:

Monoexponential apparent diffusion coefficient (ADC) analysis showed significant differences between stable and acutely deteriorating allografts.
Biexponential analysis provided higher numerical accuracy but lacked statistically significant inter-group differences in diffusion and perfusion parameters.
Unenhanced DWI is feasible for renal allograft evaluation, with ADC (mono) correlating to renal function.

Impact:

DWI provides a safe, contrast-free imaging option for renal allograft assessment.
Findings suggest ADC (mono) can serve as a biomarker for renal allograft function.
Further large-scale studies are needed to validate the clinical significance of biexponential analysis.