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Improving outcomes in hypertensive patients: focus on adherence and persistence with antihypertensive therapy

William J Elliott1

  • 1Department of Preventive Medicine, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA. wj.elliott@yahoo.com

Journal of Clinical Hypertension (Greenwich, Conn.)
|July 9, 2009
PubMed

Insights

Optimizing blood pressure (BP) control is crucial for reducing cardiovascular events. Medication adherence and persistence significantly impact BP control rates, with well-tolerated, affordable antihypertensives improving outcomes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Effective blood pressure (BP) control is vital for preventing cardiovascular events in hypertensive patients.
  • Current BP control rates in clinical practice remain suboptimal despite available treatments.
  • Medication adherence and persistence are key determinants of BP control, influencing treatment success.

Purpose of the Study:

  • To examine the impact of medication-taking behavior on blood pressure control rates.
  • To identify factors influencing adherence and persistence with antihypertensive medications.
  • To explore the role of drug efficacy, tolerability, and cost in achieving long-term BP management.

Main Methods:

  • Analysis of factors affecting medication adherence and persistence in hypertension management.
  • Review of clinical trial and outcomes study data on antihypertensive drug efficacy and tolerability.
  • Assessment of the influence of drug properties on patient adherence and discontinuation rates.

Main Results:

  • Medication adherence and persistence significantly influence blood pressure control rates.
  • Drug efficacy and tolerability are major factors affecting patient adherence and discontinuation.
  • Antihypertensive agents with fewer adverse effects are generally associated with higher adherence rates.

Conclusions:

  • Improving medication adherence and persistence is essential for optimizing blood pressure control.
  • Selecting antihypertensive agents with favorable tolerability profiles can enhance long-term patient compliance.
  • Wider use of cost-effective, well-tolerated antihypertensives may improve cardiovascular event reduction.

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