Related Experiment Video
Updated: Jun 21, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Multiple drug interactions - induced serotonin syndrome: a case report
E Montané1, A Barriocanal, I Isern
1Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Abstract:
Serotonin syndrome is a potentially life-threatening disorder of excessive serotoninergic activity often due to drug interactions. We report a case of serotonin syndrome induced by pharmacokinetic and pharmacodynamic interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin. Extreme caution is necessary in patients treated with serotonin-reuptake inhibitors who need to be switched to another antidepressant or when they require the addition of concomitant drugs, especially serotoninergic drugs and isoenzimes of cytochrome P450 inhibitors.
Related Concept Videos
Antidepressant Drugs: MAOIs and Other Agents
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
