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Cell-mediated immunity and multi-locus heterozygosity in bluethroat nestlings.
F Fossøy1, A Johnsen, J T Lifjeld
1National Centre for Biosystematics, Natural History Museum, University of Oslo, Oslo, Norway. frode.fossoy@bio.ntnu.no
Journal of Evolutionary Biology
|July 9, 2009
Summary
Microsatellite heterozygosity in bluethroat nestlings is linked to immune response. Local genetic effects, not general ones, appear to drive this correlation, influenced by meiosis and inbreeding.
Area of Science:
- Evolutionary biology
- Immunogenetics
- Population genetics
Background:
- Marker-based heterozygosity-fitness correlations are increasingly recognized in evolutionary studies.
- Previous research suggests these correlations may stem from localized genetic effects due to linkage disequilibrium with functional genes.
Purpose of the Study:
- To investigate the relationship between microsatellite heterozygosity and cell-mediated immunity in bluethroat nestlings.
- To determine if heterozygosity-fitness correlations are driven by general or local genetic effects.
Main Methods:
- Utilized a full-sibling design in bluethroat (Luscinia s. svecica) nestlings.
- Assessed cell-mediated immunity using the phytohaemagglutinin (PHA) response.
- Analyzed associations between PHA response and microsatellite heterozygosity indices (multi-locus heterozygosity and mean d(2)).
Main Results:
- Found significant positive associations between PHA response and both multi-locus heterozygosity and mean d(2).
- Model comparisons indicated that these associations were more likely due to local genetic effects rather than general effects.
- Identified two distinct genetic mechanisms potentially underlying these local effects.
Conclusions:
- Both random chromosome assortment during meiosis and inbreeding can contribute to heterozygosity-fitness correlations.
- Local heterozygosity effects, influenced by linkage disequilibrium, are crucial drivers of fitness correlations in this species.
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