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Brain natriuretic peptide a predictive marker in cardiac surgery
Saina Attaran1, Roy Sherwood, Jatin Desai
1Department of Cardiothoracic, King's College NHS Foundation Trust, London, UK. saina.attaran@kcl.ac.uk
Interactive Cardiovascular and Thoracic Surgery
|July 9, 2009
Summary
B-type natriuretic peptide (BNP) is a valuable biomarker for predicting cardiac surgery outcomes. High preoperative BNP levels correlate with increased risks like inotrope use, longer hospital stays, and mortality.
Area of Science:
- Cardiology
- Biochemistry
- Surgical Outcomes
Background:
- B-type natriuretic peptide (BNP) is a cardiac neurohormone released during myocardial stress.
- Elevated BNP levels are linked to poorer prognosis in myocardial infarction and heart failure.
- This study investigates BNP's predictive utility in cardiac surgery patients.
Purpose of the Study:
- To evaluate the usefulness of B-type natriuretic peptide (BNP) as a predictor of outcomes following cardiac surgery.
- To assess the correlation between preoperative BNP levels and various postoperative clinical endpoints.
Main Methods:
- 141 patients undergoing cardiac surgery were enrolled between March 2006 and June 2007.
- Preoperative BNP concentration and comorbidities were measured and analyzed.
- Postoperative outcomes, including atrial fibrillation, inotrope use, renal impairment, mortality, and hospital stay, were monitored.
Main Results:
- Preoperative comorbidities like renal impairment, peripheral vascular disease (PVD), and low ejection fraction (EF) were associated with higher BNP levels.
- EuroSCORE and Parsonnet scores significantly correlated with preoperative BNP.
- High preoperative BNP predicted increased inotropic support, elevated creatinine, prolonged ventilation, longer hospital stay, and early mortality (P<0.05).
Conclusions:
- B-type natriuretic peptide (BNP) is a valuable and easily measurable biochemical marker.
- BNP can aid in predicting operative outcomes in cardiac surgery patients.
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