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Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

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Published on: March 12, 2022

Cutaneous vasculitides: clinico-pathological correlation.

Suruchi Gupta¹, Sanjeev Handa, Amrinder J Kanwar

¹Department of Dermatology, Venereology, Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Dermatology, Venereology and Leprology

|July 9, 2009

Summary

Leukocytoclastic vasculitis is the most common form of cutaneous vasculitis. Early diagnosis and follow-up are crucial as skin manifestations can indicate serious systemic disease.

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Area of Science:

Dermatology
Immunology
Pathology

Background:

Cutaneous vasculitis encompasses diverse clinical and histological presentations.
Pathogenic mechanisms and clinical manifestations of vasculitis are varied.

Purpose of the Study:

To investigate the epidemiological profile of cutaneous vasculitis in a dermatology clinic.
To establish the correlation between clinical presentation and histopathological findings.

Main Methods:

A cohort of 50 patients with clinically diagnosed cutaneous vasculitis was studied.
Investigations included comprehensive blood tests, urine analysis, and imaging.
Histopathological examination and direct immunofluorescence (DIF) were performed.

Main Results:

Leukocytoclastic vasculitis was the most frequent type (41/50 patients).
Drug history was implicated in 50% of cases; infections and collagen disorders were noted in 10% each.
Histopathology confirmed vasculitis in 42 patients, and DIF was positive in 73.9% of those tested.

Conclusions:

Leukocytoclastic vasculitis is the predominant type seen in dermatology outpatient departments.
A thorough workup, including skin biopsy and DIF, is essential for diagnosis and to detect systemic involvement.
Long-term patient follow-up is critical, as cutaneous signs may herald significant systemic disease.