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Updated: Jun 21, 2026
![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-catalyzed cyclization reactions for the synthesis of alkaloids
Gwilherm Evano1, Mathieu Toumi, Alexis Coste
1Institut Lavoisier de Versailles, Université de Versailles Saint-Quentin en Yvelines, UMR CNRS 8180, 45, avenue des Etats-Unis, 78035 Versailles Cedex, France. evano@chimie.uvsq.fr
Abstract:
Copper-mediated Ullmann type transformations have recently evolved as useful and valuable synthetic tools in organic synthesis. If newly developed catalytic systems are readily available, inexpensive, and tolerate most functional groups, they also provide new opportunities in natural product synthesis since they allow new and efficient retrosynthetic disconnections. They are also especially convenient for the development of straightforward cyclization and macrocyclization procedures. The present article showcases some examples of copper-catalyzed cyclization reactions for the synthesis of alkaloids we have recently developed.
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