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Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy
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Probing a sialyltransferase's recognition domain to prepare alpha(2,8)-linked oligosialosides and analogs
Ping Zhang1, Amir J Zuccolo, Wenling Li
1Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Calgary, 2500, University Drive NW, Calgary, Alberta, Canada T2N 1N4.
Chemical Communications (Cambridge, England)
|July 9, 2009
Abstract:
We report the first observation that a monosialyl residue is the essential structural element recognized by the enzyme CST-II; this has resulted in an attractive route to synthesize a series of alpha(2,8)-linked oligosialic acids and their thioanalogs in one step.
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