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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Published on: September 12, 2019

Sorafenib: new indication. For some patients with liver cancer

    Prescrire International
    |July 10, 2009
    PubMed

    Insights

    Sorafenib therapy extended survival by approximately 3 months for patients with advanced liver cancer and good liver function. However, this treatment also led to common side effects.

    Area of Science:

    • Hepatology
    • Medical Oncology
    • Clinical Trials

    Background:

    • Hepatocellular carcinoma (HCC) is a major global health concern.
    • Effective systemic therapies for advanced HCC with preserved liver function are limited.

    Purpose of the Study:

    • To evaluate the efficacy and safety of sorafenib in patients with advanced-stage liver cancer and unimpaired hepatic function.

    Main Methods:

    • A clinical trial was conducted involving patients diagnosed with advanced-stage liver cancer.
    • Participants had maintained unimpaired hepatic function.
    • Treatment with sorafenib was administered.

    Main Results:

    • Sorafenib demonstrated a median survival benefit of approximately 3 months in 50% of the treated patients.
    • The treatment was associated with a high incidence of adverse effects.

    Conclusions:

    • Sorafenib offers a survival advantage for a subset of advanced liver cancer patients with preserved liver function.
    • The frequent adverse effects necessitate careful patient monitoring and management strategies.

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