Related Experiment Video
Updated: Jun 21, 2026
06:12
Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition
Published on: March 3, 2023
Nicotine-induced osteonecrosis. A case report
1Newcastle Dental Hospital, Richardson Road, Newcastle Upon Tyne NE2 4BW, UK.
Dental Update
|July 10, 2009
Summary
Nicotine chewing gum can cause oral ulcerations due to prolonged contact with the alveolar mucosa. Regular chewing aids nicotine dispersal, minimizing this risk for patients using nicotine replacement therapy.
Area of Science:
- Oral medicine
- Pharmacology of nicotine replacement therapy
Background:
- Nicotine replacement therapy (NRT) is widely used for smoking cessation.
- Understanding the local effects of NRT on the oral cavity is crucial for patient care.
Observation:
- A previously undocumented side-effect of nicotine chewing gum involves oral ulceration.
- Prolonged, localized contact between the gum and the alveolar mucosa appears to be a contributing factor.
Findings:
- Nicotine exposure can negatively impact the oral environment.
- Specific areas of ulceration in patients using nicotine gum warrant consideration of this side-effect.
Implications:
- Clinicians should advise patients using nicotine gum to avoid prolonged contact with the alveolar mucosa.
- Educating patients on proper chewing technique promotes nicotine dispersal and may prevent adverse oral effects.
