Related Experiment Video
Updated: Jun 21, 2026

Functional Complementation Analysis (FCA): A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
Published on: June 24, 2016
[Phenylketonuria]
Harri Niinikoski1, Jaana Heikkilä, Kirsti Näntö-Salonen
1TYKS:n lastenklinikka, Kiinamyllynkatu 4-8, 20520 Turku.
Abstract:
Owing to our special genetic heritage, phenylketonuria is very rare in Finland, but the situation will change as the number of immigrants from populations with a larger incidence increases. In persons with this disorder, the enzyme phenylalanine hydroxylase, which metabolizes phenylalanine to tyrosine, is not functioning normally, leading to the accumulation phenylalanine within the body. High levels of phenylalanine are toxic to the central nervous system. A newborn affected with phenylketonuria is asymptomatic but will rapidly become disabled without therapy. The leading principle of the therapy is careful limitation of phenylalanine intake.
More Related Videos
11:31Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
Published on: September 18, 2013
10:38Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
Published on: May 9, 2020
Related Concept Videos
Inborn Errors of Metabolism
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Diabetic Ketoacidosis l: Introduction
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption