Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary 3'-sialyllactose reduces sensitization and type 2 inflammation in a house dust mite induced acute allergic asthma model.

Frontiers in allergy·2025
Same author

Effects of galacto-oligosaccharides and microbiota transfer on lung health and performance of calves.

Journal of dairy science·2025
Same author

Retraction Note: Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial.

European journal of clinical nutrition·2025
Same author

Butyrate interacts with the effects of 2'FL and 3FL to modulate <i>in vitro</i> ovalbumin-induced immune activation, and 2'FL lowers mucosal mast cell activation in a preclinical model for hen's egg allergy.

Frontiers in nutrition·2024
Same author

Effects of nondigestible oligosaccharides on inflammation, lung health, and performance of calves.

Journal of dairy science·2023
Same author

Leucine-enriched essential amino acid supplementation in mechanically ventilated trauma patients: a feasibility study.

Trials·2019

Related Experiment Video

Updated: Jun 21, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Inflammatory disease processes and interactions with nutrition.

P C Calder1, R Albers, J-M Antoine

  • 1School of Medicine, University of Southampton, Southampton SO16 6YD, UK.

The British Journal of Nutrition
|July 10, 2009
PubMed
Summary
This summary is machine-generated.

Regulated inflammation is vital for health, but chronic inflammation drives disease. Dietary components may offer anti-inflammatory benefits, though more human studies are needed to confirm efficacy and mechanisms.

More Related Videos

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Immunology and Nutrition Science

Background:

  • Inflammation is a critical physiological response to injury and infection, essential for pathogen elimination and tissue repair.
  • While acute inflammation is typically self-limiting, dysregulated responses can become chronic, contributing to disease progression.
  • Chronic inflammation is characterized by barrier dysfunction, aberrant cellular infiltration, and overproduction of inflammatory mediators.

Purpose of the Study:

  • To review the potential role of dietary components in modulating chronic inflammatory conditions.
  • To explore the mechanisms by which these dietary factors may exert anti-inflammatory effects.
  • To highlight the need for further human studies to validate efficacy and elucidate mechanisms.

Main Methods:

  • Literature review of dietary components with potential anti-inflammatory properties.
  • Analysis of proposed mechanisms of action for these components.
  • Assessment of the current evidence for human health benefits.

Main Results:

  • Dietary components like omega-3 fatty acids, antioxidant vitamins, flavonoids, prebiotics, and probiotics may influence inflammatory pathways.
  • Mechanisms include reduced mediator production, decreased oxidant generation, and improved gut barrier function.
  • Currently, strong clinical evidence for the anti-inflammatory benefits of most dietary components in humans is limited.

Conclusions:

  • Dietary interventions show promise for managing chronic inflammation, but robust human data are scarce.
  • Further research is essential to confirm the efficacy of these components and understand their precise mechanisms in vivo.
  • Well-designed human trials are required to establish the therapeutic potential of dietary strategies for inflammatory diseases.