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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Skin markers of communicating dermal sinus: report of two cases]
N Dallot-Le Saché1, L Yazigi-Rivard, T Roujeau
1Service de réanimation néonatale et pédiatrique, hôpital Armand-Trousseau, AP-HP, UPMC Paris-VI, Paris cedex 12, France.
Insights
Infants with skin abnormalities in the lumbosacral region may have underlying spinal malformations like dermal sinus. Early detection and surgery are crucial to prevent severe complications such as meningitis and neurological deficits.
Area of Science:
- Pediatric Neurology
- Dermatology
- Neurosurgery
Background:
- Skin abnormalities in the spinal lumbosacral region of infants are common.
- Physicians must consider underlying spinal malformations when these lesions are present.
Observation:
- This report details two infant cases where a dermal sinus was identified due to severe meningitis.
- Dermal sinus is an abnormal tract connecting skin to neural structures, often in the lumbosacral area.
- Associated skin findings include hypertrichosis, lipomas, and hyperpigmented lesions.
Findings:
- Dermal sinus can lead to recurrent bacterial meningitis or meningitis from unusual bacteria.
- Neurological abnormalities such as sensory changes, motor weakness, and bowel/bladder dysfunction can occur.
- Infants may present with subtle symptoms like delayed walking or sphincter control issues.
Implications:
- Early diagnosis of dermal sinus is critical to prevent severe neurological and orthopedic complications.
- Magnetic resonance imaging (MRI) is essential for diagnosis when suspected.
- Prompt surgical intervention can prevent long-term adverse outcomes in affected infants.
Abstract:
Skin abnormalities in the spinal lumbosacral region of infants are not infrequent. Physicians should look for underlying spinal malformations. We report 2 cases of dermal sinus in infants revealed by severe, acute meningitis. The dermal sinus is an abnormal tract between the skin and underlying neural structures, most often located in the lumbosacral region. It may end blindly in the subcutaneous tissues, or it may extend into the medullary space. The diagnosis should be suspected in patients with other skin findings: localized hypertrichosis, subcutaneous lipomas, hyperpigmented lesions, etc. It must be distinguished from the very frequent coccygeal pits (4% of newborns), which require no treatment. Magnetic resonance imaging should be done every time the diagnosis is suspected. Recurrent bacterial meningitis or meningitis caused by unusual bacteria is frequently associated with dermal sinus. A variety of neurologic abnormalities have been described: sensory changes, motor weakness, reflex changes, abnormal bowel and bladder function, etc. Infants generally have few neurologic symptoms, such as delayed walking or sphincter control. Orthopaedic abnormalities are rare. The dermal sinus tract needs to be detected at an early stage in order to avoid these complications, which can be prevented by early surgery.
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