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Related Experiment Video

Updated: Jun 21, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
11:02

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos

Published on: April 29, 2011

[The expression analysis of Grb10 during mouse embryonic development].

Qi Liu1, Yan Wang, Yan Chen

  • 1Developmental Biology Lab, Department of Life Science and Engineering, Harbin Institute of Technology, Harbin 150001, China. liuqi.ssc@2004.hit.edu.cn

Yi Chuan = Hereditas
|July 10, 2009
PubMed
Summary

Growth factor receptor-bound protein 10 (Grb10) gene expression varies during mouse embryonic development. Grb10 shows dynamic expression patterns in fetal tissues, suggesting a key role in mouse development.

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Last Updated: Jun 21, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
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Area of Science:

  • Developmental Biology
  • Gene Expression Analysis

Context:

  • The Grb10 gene plays a role in cellular signaling pathways.
  • Understanding gene expression during embryonic development is crucial for identifying developmental regulators.

Purpose:

  • To analyze the spatiotemporal expression pattern of the Grb10 gene during mouse embryonic development.
  • To investigate the role of Grb10 in fetal organogenesis.

Summary:

  • Real-time RT-PCR revealed Grb10 expression from embryonic day (E) 8.5 to E19.5, with increasing levels until E13.5, followed by a decrease.
  • Tissue-specific analysis showed declining Grb10 levels in brain, heart, and lung from E12.5 to E19.5, but a peak in the liver at E18.5.
  • In situ hybridization identified strong Grb10 signals in brain, spine, kidney, and muscle tissues at various embryonic stages.

Impact:

  • These findings highlight the dynamic expression of Grb10 during mouse development.
  • The results suggest Grb10 is a significant factor in embryonic development and organogenesis.