Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Development of the Oral Microbiota

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Pain and dysfunction of the temporomandibular joint: etiology and treatment].

Harefuah·1992

Same author

Prenatal diagnosis of tetrasomy 12p by in situ hybridization: varying levels of mosaicism in different fetal tissues.

Prenatal diagnosis·1992

Same author

Use of esterase inhibitors and zone electrophoresis to define bacterial esterases in amniotic fluid.

American journal of obstetrics and gynecology·1992

Same author

Phantom limbs still a ghostly phenomenon.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1992

Same author

Impact of vitamin A supplementation on the incidence of infection in elderly nursing-home residents: a randomized controlled trial.

Age and ageing·1992

Same author

The increased risk of ulcerative keratitis among disposable soft contact lens users.

Archives of ophthalmology (Chicago, Ill. : 1960)·1992

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

Localization of P. gingivalis in preterm delivery placenta.

J Katz¹, N Chegini, K T Shiverick

¹Department of Oral Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, PO Box 100414, Gainesville, FL 32610, USA. jkatz@dental.ufl.edu

Journal of Dental Research

|July 10, 2009

Summary

Periodontal disease, specifically Porphyromonas gingivalis, was found in placental tissues of women with chorioamnionitis. This suggests a link between oral bacteria and adverse pregnancy outcomes like preterm delivery.

Related Experiment Videos

Last Updated: Jun 21, 2026

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA

Published on: May 21, 2015

Area of Science:

Obstetrics and Gynecology
Periodontology
Infectious Diseases

Background:

Periodontal disease is increasingly linked to adverse pregnancy outcomes.
The presence of oral bacteria in placental tissue during chorioamnionitis has not been previously demonstrated.
Infection is a known risk factor for preterm delivery.

Purpose of the Study:

To investigate the hypothesis that periodontal pathogens are present in human placenta during chorioamnionitis.
To determine if Porphyromonas gingivalis antigens can be detected in placental tissues.

Main Methods:

Immunocytochemistry was used to detect Porphyromonas gingivalis antigens.
Placental tissues from women with chorioamnionitis and normal-term pregnancies were analyzed.
Immunostaining intensity was compared between the two groups.

Main Results:

Porphyromonas gingivalis antigens were identified in placental syncytiotrophoblasts, chorionic trophoblasts, decidual cells, amniotic epithelial cells, and vascular cells.
A significant increase in immunostaining intensity was observed in tissues from women with chorioamnionitis compared to normal-term pregnancies (p < 0.019).

Conclusions:

Porphyromonas gingivalis commonly colonizes placental tissue.
The presence of P. gingivalis in the placenta may contribute to adverse pregnancy outcomes, including preterm delivery.