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Related Experiment Video

Updated: Jun 21, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Preventing stroke: the PRoFESS, ONTARGET, and TRANSCEND trial programs.

Hans-Christoph Diener¹

¹Department of Neurology, University of Duisburg-Essen, Essen, Germany. h.diener@uni-essen.de

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension

|July 10, 2009

Summary

Telmisartan, an angiotensin II receptor blocker, showed a significant reduction in recurrent strokes after six months in the PRoFESS trial. Combined analyses suggest telmisartan may reduce secondary stroke risk and composite vascular events.

Related Experiment Videos

Last Updated: Jun 21, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Area of Science:

Cardiovascular Medicine
Neurology
Pharmacology

Background:

Renin-angiotensin system (RAS) blockers may reduce stroke risk beyond blood pressure effects.
Angiotensin II receptor blocker (ARB) telmisartan has shown potential in preventing secondary strokes.

Purpose of the Study:

To evaluate the efficacy of telmisartan in reducing recurrent stroke risk.
To assess the impact of telmisartan on secondary stroke prevention in patients with prior ischemic stroke.

Main Methods:

The PReventiOn regimen For Effectively avoiding Second Strokes (PRoFESS) trial randomized 20,332 ischemic stroke patients to telmisartan or placebo.
Post-hoc analysis of PRoFESS data assessed outcomes from 6 months.
Telmisartan's effect was also examined in the stroke subgroup of the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and the Telmisartan Randomized AssessmeNt Study in aCE-iNtolerant subjects with cardiovascular Disease (TRANSCEND).

Main Results:

In PRoFESS, telmisartan showed a nonsignificant reduction in recurrent stroke over 2 years (HR 0.95).
A post-hoc analysis revealed a significant reduction in strokes from 6 months (HR 0.88; P=0.042).
Combined analysis of PRoFESS and TRANSCEND showed a significant reduction in the composite of stroke, myocardial infarction, or vascular death (HR 0.91; P=0.013).

Conclusions:

Telmisartan demonstrated a significant benefit in reducing recurrent strokes from 6 months post-stroke.
Telmisartan, as an ARB, may offer protective effects against secondary strokes and composite vascular events.