Related Experiment Video
Updated: Jun 21, 2026

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
Published on: January 20, 2023
Stroke mimicking encephalopathy as an initial manifestation of diffuse large B-cell lymphoma
Jeong-Min Kim1, Keun-Hwa Jung, Soon-Tae Lee
1Department of Neurology, Stroke & Neural Stem Cell Laboratory in the Clinical Research Institute, Stem Cell Research Center, Seoul National Hospital, Seoul, Korea.
Background:
Systemic lymphoma can be difficult to recognize due to its diverse manifestations. Paraneoplastic leukoencephalopathy has rarely been reported in the context of lymphoma.
Case Report:
We report a 45-year-old man with systemic lymphoma whose initial manifestation was sudden-onset leukoencephalopathy, mimicking stroke. This patient, who was eventually diagnosed with diffuse large B-cell lymphoma, initially presented with sudden cognitive impairment and gait disturbance. Radiological studies suggested a paraneoplastic leukoencephalopathy. Chemotherapy for lymphoma resulted in clinical and radiological improvement.
Conclusions:
The presented case indicates that diffuse large B-cell lymphoma may initially appear as a treatable leukoencephalopathy.
Related Concept Videos
Hemorrhagic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
