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Updated: Jun 21, 2026

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Analysis of Global RNA Synthesis at the Single Cell Level following Hypoxia
Published on: May 13, 2014
The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides
Nan Zhang1, Chunyan Tan, Puqin Cai
1Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China.
Abstract:
Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.
