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Related Experiment Video

Updated: Jun 21, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Neurocognitive dysfunction in patients with obsessive compulsive disorder.

J K Trivedi¹, M Dhyani, D Goel

¹Department of Psychiatry, King George's Medical University, Lucknow, India.

African Journal of Psychiatry

|July 10, 2009

Summary

Obsessive-compulsive disorder (OCD) patients show significant cognitive deficits compared to controls, particularly in executive functions and memory. Illness severity, not duration, correlates with poorer cognitive performance in these patients.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Dysfunctional prefrontal-striatal systems are often implicated in obsessive-compulsive disorder (OCD).
Neuropsychological evidence supporting these cognitive deficits in OCD remains inconclusive.

Purpose of the Study:

To investigate neurocognitive dysfunctions in OCD patients compared to healthy controls.
To examine the relationship between illness duration, disease severity, and neurocognitive deficits in OCD.

Main Methods:

Thirty OCD patients and thirty matched controls underwent computer-based assessments.
Evaluated executive functions, vigilance, and spatial working memory.

Main Results:

OCD patients exhibited poorer performance across all neurocognitive measures compared to controls.
Higher illness severity positively correlated with worse performance on the Continuous Performance Test (CPT).
No significant correlation was found between illness duration and cognitive parameters.

Conclusions:

OCD patients demonstrate significant cognitive impairments compared to controls, impacting functional outcomes.
Disease severity distinguishes OCD patients in neuropsychological terms, highlighting varied cognitive impairment profiles.