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Democratization and integration of genomic profiling tools
Michael R Sussman1, Edward L Huttlin, Dana J Wohlbach
1Department of Biochemistry, UW Biotechnology Center, University of Wisconsin-Madison, Madison, WI, USA.
Methods in Molecular Biology (Clifton, N.J.)
|July 10, 2009
Summary
Systems biology uses quantitative profiling to understand life's evolution by examining genetic and environmental effects on cells. This review evaluates genomic techniques for plant systems biology and suggests future directions.
Area of Science:
- Plant Systems Biology
- Genomics
- Molecular Biology
Background:
- Systems biology aims for a holistic understanding of organismal function.
- It involves quantitatively profiling genetic and environmental perturbations on cellular states.
- Recreating and measuring evolutionary states is a key goal.
Purpose of the Study:
- To review and evaluate genomic profiling techniques in plant systems biology.
- To provide recommendations for advancing the use and integration of these techniques.
Main Methods:
- Quantitative profiling of genetic and environmental perturbations.
- Analysis of changes in transcriptome, proteome, and metabolome.
- Review and evaluation of existing genomic profiling techniques.
Main Results:
- Identification of key genomic profiling techniques relevant to plant systems biology.
- Evaluation of the strengths and limitations of current methods.
- Recommendations for future progress and integration of techniques.
Conclusions:
- Genomic profiling techniques are crucial for advancing plant systems biology.
- Further development and integration of these methods are needed for comprehensive understanding.
- This work guides future research in plant systems biology.
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