Related Experiment Video
Updated: Jun 21, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
[Can HRT be a useful tool in differentiating lamellar macular holes from full-thickness macular holes?]
Z Michalewska1, J Michalewski, J Nawrocki
1Klinika Okulistyczna Jasne Blonia, Lodz, Polen. zosia_n@yahoo.com
Background:
The aim of this prospective study was to analyze the specificity and sensitivity of HRT 3 compared with spectral optical coherence tomography (SOCT) in differentiating full-thickness macular holes, lamellar macular holes, and macular pseudoholes.
Material And Methods:
In 128 patients with a diagnosis made by SOCT of full-thickness macular hole, lamellar macular hole, or macular pseudohole, 161 eyes were examined with the HRT 3 Retina Module, and the results were compared.
Results:
Using SOCT, full-thickness macular holes were diagnosed in 80 eyes, pseudoholes in 15 eyes, and lamellar macular holes in 66 eyes. Using HRT, full-thickness macular holes were diagnosed in 81 eyes, and pseudoholes and lamellar macular holes (non-full-thickness macular holes) were diagnosed in 80 eyes. In 160/161 cases, the diagnosis with HRT 3 was correct. Compared with SOCT, HRT 3 has a specificity of 98.7% and a sensitivity of 100% in differentiating full-thickness from non-full-thickness macular holes.
Conclusion:
The HRT 3 macular module enables diagnosis of macular holes. Full-thickness macular holes could be differentiated from non-full-thickness macular holes; however, lamellar macular holes could not be differentiated from macular pseudoholes.

