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Updated: Jun 21, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
M-protein-positive chronic active Epstein-Barr virus infection: features mimicking HIV-1 infection
Shinsaku Imashuku1, Naoto Azuma2, Hirokazu Kanegane3
1Division of Pediatrics and Hematology, Takasago-seibu Hospital, 1-10-41, Nakasuji Takasago, Hyogo, 676-0812, Japan. shinim95@mbox.kyoto-inet.or.jp.
Abstract:
Chronic active Epstein-Barr virus infection (CAEBV) is a unique and fatal lymphoproliferative disease (LPD), which often shows high serum IgG and/or IgE. The significance of such immunoglobulin abnormalities in CAEBV has not been fully evaluated and discussed. In addition, such clinical features mimic HIV-1 infection. We report here a case of CAEBV with M-protein detected which may shed a new light on the pathogenesis of this disease.

