Related Experiment Video
Updated: Jun 21, 2026
05:18
Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
Corticosteroid injection for de Quervain's tenosynovitis
Cyriac Peters-Veluthamaningal1, Daniëlle A W M van der Windt, Jan C Winters
1Department of General Practice, University Medical Center Groningen, Antonius Deusinglaan 1, Groningen, Netherlands, 9713 AV.
The Cochrane Database of Systematic Reviews
|July 10, 2009
Summary
Corticosteroid injections effectively treat de Quervain's tenosynovitis, offering superior pain relief compared to splinting. Further research is needed due to the limited scope of current evidence.
Area of Science:
- Orthopedics
- Rheumatology
- Evidence-based medicine
Background:
- De Quervain's tenosynovitis causes wrist pain and functional limitation.
- Common treatments include corticosteroid injections, splinting, and surgery.
Purpose of the Study:
- To evaluate the efficacy and safety of corticosteroid injections for de Quervain's tenosynovitis.
- To summarize existing evidence on this treatment modality.
Main Methods:
- Systematic review of randomized and controlled clinical trials.
- Searched multiple databases including Cochrane, MEDLINE, EMBASE, CINAHL, AMED, DARE, Dissertation Abstracts, and PEDro.
- Assessed methodological quality using Jadad and Delphi lists; extracted data on efficacy and safety outcomes.
Main Results:
- One controlled trial (18 pregnant/lactating women) compared corticosteroid injection to thumb spica splinting.
- All patients receiving steroid injections (9/9) experienced complete pain relief within 1-6 days (NNTB=1).
- No patients in the splinting group (0/9) achieved complete pain relief; no side effects were reported.
Conclusions:
- Corticosteroid injections demonstrated superiority over thumb spica splinting in a single trial.
- Limited applicability to general practice due to small sample size, poor methodology, and specific population.
- No adverse effects were observed in the included study.
Related Concept Videos
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:17Pericarditis III: Medical Management
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...