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Related Experiment Video

Updated: Jun 21, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

The kidney transplant failure experience: a longitudinal case study.

Paul Gill¹, Lesley Lowes

¹Faculty of Health, Sport & Science, University of Glamorgan, Pontypridd, United Kingdom CF37 1DL. PWGill@glam.ac.uk

Progress in Transplantation (Aliso Viejo, Calif.)

|July 11, 2009

Summary

Kidney transplant failure is devastating, causing grief and depression linked to the loss of anticipated future. Improved support for patients and families before and after transplantation is crucial.

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Area of Science:

Nephrology
Transplant Surgery
Psychology

Background:

Kidney transplants offer significant benefits but have a failure rate of 7-12% within a year.
Graft failure can lead to severe psychological distress, including depression and suicidal ideation.
The personal impact of kidney transplant failure remains under-researched.

Observation:

A longitudinal case study examined a donor-recipient couple's experience with immediate irreversible graft rejection.
Data were collected through semistructured interviews at three time points: pre-transplant, and 3 and 10 months post-transplant.
The recipient experienced profound grief, loss, and depression following graft rejection.

Findings:

Transplantation initially offered hope, with emotion-focused coping used to manage fear of failure.
Graft rejection was devastating, leading to feelings of loss and depression.
The recipient reported inadequate preparation and support from healthcare professionals regarding transplant failure.

Implications:

The recipient's grief was primarily linked to the "loss of imagined future" post-transplant.
Findings highlight the need for enhanced patient and family support, information, and care before and after kidney transplantation.
Further research into the psychological dimensions of transplant failure is warranted.