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Comprehensive &amp; Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
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Local reference ranges for full blood count and CD4 lymphocyte count testing.

Denise Lawrie1, Lindi Marie Coetzee, Piet Becker

  • 1Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg. denise.lawrie@nhls.ac.za

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|July 11, 2009
PubMed
Summary

New reference ranges for full blood count and CD4 analysis are needed in Gauteng due to demographic shifts. Ethnic-specific ranges for neutrophils and lymphocytes, and local ranges for RDW and CD4 percentage are recommended.

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Area of Science:

  • Hematology
  • Immunology
  • Clinical Pathology

Background:

  • Demographic changes in Gauteng necessitate updated reference ranges for hematological parameters.
  • Advances in full blood count (FBC) and CD4 count technology require reevaluation of current standards.

Purpose of the Study:

  • To establish current, accurate reference ranges for FBC and CD4 counts in the Gauteng population.
  • To identify gender and ethnic variations in hematological parameters.

Main Methods:

  • Cross-sectional study of 631 females and 88 males in Gauteng.
  • Analysis using the latest FBC, automated differential, and CD4 count technology.
  • Reference ranges determined by 2.5th and 97.5th percentiles; non-parametric tests for comparisons.

Main Results:

  • Gender-specific differences observed in red blood cell and platelet parameters.
  • Ethnic-specific differences noted in red blood cell parameters for black females.
  • Black males and females exhibited lower neutrophil and higher lymphocyte counts compared to other ethnic groups.

Conclusions:

  • Introduction of ethnic-specific reference ranges for neutrophil and lymphocyte percentages is recommended.
  • Implementation of locally derived reference ranges for red cell distribution width (RDW) and CD4 percentage is advised for routine diagnostics.