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Updated: Jun 21, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Mixed surfactant based microemulsions as vehicles for enhanced solubilization and synthesis of organoselenium
S K Mehta1, Khushwinder Kaur, Ekta Arora
1Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160 014 India. skmehta@pu.ac.in
Abstract:
We exploited the added degree of compositional freedom provided by mixed AOT/lecithin surfactants in reverse isooctane microemulsion to demonstrate that a small amount of added lecithin significantly enhances the solubility of organodiselenides over that in AOT reverse isooctane microemulsions alone. Conductivity results show that the added lecithin significantly increases the solubility of four different organodiselenides and raises the temperature required to induce percolation. FTIR, (1)H NMR, and UV-visible techniques were utilized to gain insight into the interactions of organodiselenides, AOT and lecithin headgroups with water in the micellar core. The information obtained from these experiments was used to design a novel synthetic route for preparing 4-chloro-2-(naphthalen-2-ylselanyl) pyrimidine in reverse microemulsion.
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