Related Experiment Video
Updated: Mar 2, 2026
06:20
Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
120
Bilateral Wilms' tumor: the need to improve outcomes
1Children Oncology Group, Ann Arbor, MI 48109, USA. pehrlich@med.umich.edu
Expert Review of Anticancer Therapy
|July 11, 2009
Summary
Bilateral Wilms tumor (BWT) treatment outcomes are reviewed, highlighting survival rates based on histology. This analysis informs future therapeutic strategies for pediatric kidney cancer.
Area of Science:
- Pediatric Oncology
- Nephrology
- Surgical Oncology
Background:
- Wilms tumor (WT) is the most common pediatric kidney cancer.
- Treatment has shifted to a risk-based approach.
- Bilateral Wilms tumor (BWT) patients lack dedicated clinical study.
Purpose of the Study:
- Review outcomes for synchronous BWT.
- Discuss surgical considerations for BWT.
- Propose future research directions for BWT.
Main Methods:
- Review of outcomes from National WT Study-5 for BWT patients.
- Analysis of survival rates stratified by histology.
- Synthesis of current surgical approaches.
Main Results:
- Survival rates for BWT range from 61-80.8% (favorable histology) to 43.8% (unfavorable histology).
- Significant survival disparity exists based on tumor histology.
- Current data highlights the need for improved BWT management.
Conclusions:
- BWT treatment requires further dedicated study.
- Risk-stratified approaches are crucial for optimizing BWT outcomes.
- Future research should focus on novel therapeutic strategies for BWT.
Related Concept Videos
01:28Kidney Transplant I: Introduction
599
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
599
01:16Kidney Transplant III: Nursing Management
456
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
456
01:26Kidney Transplant II: Surgical Procedure
581
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
581
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K