Radiation induced acute tumor lysis syndrome in the bone marrow transplant setting

Patients with highly chemo-responsive malignancies have for some time been known to be at risk for life threatening acute tumor lysis syndrome (TLS). This report describes two cases involving acute TLS in patients with malignant diseases which had become refractory to therapy and received initial total body irradiation as a part of the preparative regimen for allogeneic bone marrow transplantation.