Related Experiment Video
Updated: Jun 21, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Preparation, characterization and dissolution studies of fast release diclofenac sodium tablets from PVP solid
Maria Celina Lamas1, Darío Leonardi, Osvaldo A Lambri
1Departamento Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina. mlamas@fbioyf.unr.edu.ar
Abstract:
Diclofenac sodium is a non-steroidal anti-inflammatory drug widely used in the treatment of ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. In this context, a rapid onset of action is required. Thus, the aim of this study was to formulate diclofenac sodium-PVP K-30 fast release tablets from solid dispersions. The physical state and drug:carrier interactions were analyzed by X-ray diffraction and scanning electron microscopy and stability upon storage was also studied. Dissolution rate of diclofenac sodium from solid dispersions was markedly enhanced by increasing the polymer concentration.
More Related Videos
08:59A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
07:32Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Drug Dissolution: Requirements and Profile Comparison
In Vitro Drug Dissolution: Alternative Methods
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
In Vitro Drug Dissolution: Compendial Testing Models II
Oral Drug Delivery Systems: Delayed-Release Systems