Related Experiment Video
Updated: Jun 21, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Pedigree analysis for conservation of genetic diversity and purging
1Department of Mathematics, University of Kassel, D-34109 Kassel, Germany. wellmann@mathematik.uni-kassel.de
Abstract:
We present an approach to describe and evaluate changes in genetic diversity and to calculate bounds for improvement. This pedigree-based analysis was applied to the Kromfohrländer dog (FCI Gr9 Sec10). Pedigrees trace back to the foundation of the breed and were available for 5527 individuals. Based on this dataset the population structure and historical bottlenecks were studied. Distributions of allele frequencies were estimated by Monte Carlo simulation. To monitor changes in mating systems throughout the breeding history, the homozygosity of alleles was compared with their expectations in Hardy-Weinberg equilibrium. Different breeding lines were identified by hierarchical cluster analysis and were characterized by ancestor contributions. Our calculations showed that the founder event in 1945 was followed by two bottlenecks. One was caused by strong selection in a very small population, and the other was triggered by rigorous disease management. The necessary amount of purging that arised due to the bottlenecks was also discussed.
Related Concept Videos
Pedigree Analysis
Pedigree Analysis
Evolutionary Relationships through Genome Comparisons
Genetic Variation
Genes exist in different versions called alleles, which...
Mutation, Gene Flow, and Genetic Drift
Incomplete Dominance

