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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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Early decrease in resting energy expenditure with bedtime insulin therapy.

C Fagour1, C Gonzalez, C Suberville

  • 1hôpital Haut-Lévêque, CHU de Bordeaux, Pessac, France. cedricfagour@hotmail.com

Diabetes & Metabolism
|July 11, 2009
PubMed
Summary
This summary is machine-generated.

Introducing bedtime insulin in type 2 diabetes (T2D) patients may reduce resting energy expenditure (REE) early on. This finding suggests a potential mechanism for insulin-associated weight gain in T2D management.

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Area of Science:

  • Metabolism and Endocrinology
  • Diabetes Mellitus Research

Background:

  • Insulin therapy in type 2 diabetes (T2D) can lead to weight gain.
  • Reduced resting energy expenditure (REE) is a potential contributor to insulin-induced weight gain.

Purpose of the Study:

  • To investigate the early impact of insulin introduction on REE in patients with poorly controlled T2D.
  • To compare the effects of bedtime subcutaneous insulin versus intravenous insulin infusion on REE.

Main Methods:

  • 20 patients with T2D had their REE measured before and after 4 days of treatment.
  • Two groups received either bedtime subcutaneous insulin or a 3-day intravenous insulin infusion.
  • Glycemic control was improved in both groups prior to REE measurements.

Main Results:

  • Both treatment regimens similarly improved fasting blood glucose levels.
  • Resting energy expenditure (REE) did not change in the intravenous insulin group (-1.3%).
  • A significant decrease in REE was observed in the bedtime insulin group (-8.0%; P<0.05).

Conclusions:

  • Early introduction of bedtime subcutaneous insulin is associated with a significant reduction in resting energy expenditure.
  • This early reduction in REE may represent a specific mechanism contributing to weight gain in type 2 diabetes patients on insulin therapy.