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Adiponectin in children on peritoneal dialysis: relationship to insulin resistance and nutritional status

Mariana Kamariski1, Mónica Biscardi, Laura Cestino

  • 1Area de Fisiopatología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.

Nephron. Clinical Practice
|July 11, 2009
PubMed

Insights

In pediatric peritoneal dialysis (PD) patients, higher adiponectin levels correlate with lower body mass index (BMI) and body fat, suggesting a role in clinical wasting. Resistin levels did not differ significantly among groups.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Nutritional Science

Background:

  • Peritoneal dialysis (PD) in children can impact nutritional status and metabolic health.
  • Adiponectin and resistin are adipokines with known roles in metabolism and inflammation, but their specific associations in pediatric PD patients are not well-defined.

Purpose of the Study:

  • To investigate the relationship between serum adiponectin and resistin levels and insulin resistance (IR) and anthropometric parameters in children undergoing PD.
  • To compare these parameters between PD patients, chronic kidney disease (CKD) patients, and healthy controls.

Main Methods:

  • Oral glucose tolerance test to measure glucose and insulin.
  • Enzyme-linked immunosorbent assay (ELISA) for adiponectin and resistin.
  • Radioimmunoassay (RIA) for insulin.

Main Results:

  • PD patients exhibited significantly higher adiponectin levels and lower body mass index (BMI) and body fat content compared to controls.
  • CKD patients showed higher insulin resistance (IR) markers (HOMA-IR, fasting and 2-hour insulin) than controls and PD patients.
  • Adiponectin was inversely associated with BMI, weight, height z-score, and body fat, but not directly with IR parameters. Both adiponectin and resistin correlated negatively with glomerular filtration rate.

Conclusions:

  • Adiponectin may play a role in the clinical wasting observed in pediatric PD patients, as indicated by its association with reduced anthropometric parameters.
  • Further research is warranted to elucidate the precise mechanisms linking adiponectin to nutritional status in this population.
Abstract

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