Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
10:00

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

Extraction of a chronically implanted, microfabricated, subretinal electrode array.

Jinghua Chen1, Hassan A Shah, Charles Herbert

  • 1Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Mass. 02114, USA.

Ophthalmic Research
|July 11, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

α-Linolenic Acid-Modified Collagen for Surgical Sutures: Water-Resistant, Anti-inflammatory, and Antibacterial.

ACS biomaterials science & engineering·2026
Same author

Endovascular treatment of intracranial vertebral artery dissecting aneurysm in a patient with aplastic anemia: A case report and literature review.

SAGE open medical case reports·2026
Same author

pH-responsive human serum albumin nanoparticles for amphotericin B delivery: Enhanced antifungal efficacy and reduced nephrotoxicity.

International journal of biological macromolecules·2026
Same author

The mediating role of healthy lifestyle in the association between higher socioeconomic status and an increased risk of allergic rhinitis: an analysis of NHANES.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

Appropriate Dietary Levels of Soybean Lecithin and Krill Oil Phospholipids Promote Growth, Antioxidant Capacity, and Lipid Metabolism While Reducing Lipid Deposition in Atlantic Salmon (<i>Salmo salar</i>) Fry.

Animals : an open access journal from MDPI·2026
Same author

Chito-oligosaccharide-reinforced thermally cross-linked fish skin gelatin films with silver nanoparticles: Enhanced properties and accelerated wound healing.

Carbohydrate polymers·2026
Same journal

Retraction Statement.

Ophthalmic research·2026
Same journal

Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-naïve Ethnic Han Chinese Thyroid Eye Disease.

Ophthalmic research·2026
Same journal

Stem Cell Based Interventions for Retinal Ganglion Cell Protection and Regeneration in Glaucoma: A Review of Current Evidence and Future Directions.

Ophthalmic research·2026
Same journal

Eye-Tracking Reading Patterns as Correlates of Clinical Measures in Glaucoma.

Ophthalmic research·2026
Same journal

A Matching-Adjusted Comparison of Faricimab and Aflibercept 8 mg in Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema.

Ophthalmic research·2026
Same journal

Ab Externo Continuous Pressure Technique for Descemet Membrane Endothelial Keratoplasty in Vitrectomized Eyes.

Ophthalmic research·2026
See all related articles

Subretinal electrode arrays can be safely removed from rabbit eyes two months after implantation. This study demonstrates the feasibility of extracting these devices, minimizing potential complications from scar tissue.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Chronic implantation of subretinal electrode arrays is a key strategy for vision restoration.
  • Assessing the long-term safety and removability of these implants is crucial for clinical translation.

Purpose of the Study:

  • To evaluate the feasibility and safety of extracting chronically implanted subretinal electrode arrays.
  • To determine the optimal timing for removal, considering potential postoperative scarring.

Main Methods:

  • Polyimide electrode arrays were implanted into the subretinal space of rabbits.
  • Surgical extraction was performed two months post-implantation.
  • Ophthalmic examinations, electroretinography, and histology were used to assess outcomes.

More Related Videos

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
12:01

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

Related Experiment Videos

Last Updated: Jun 21, 2026

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
10:00

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Published on: February 14, 2015

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
12:01

Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis

Published on: August 2, 2013

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

Main Results:

  • Successful placement and subsequent extraction of subretinal arrays were achieved in all cases.
  • No significant complications were observed during extraction surgeries.
  • Histological analysis revealed mild, localized anatomical changes post-explantation.

Conclusions:

  • Subretinal electrode arrays can be reliably extracted from rabbit eyes two months after implantation.
  • This timing avoids the period of most intense postoperative scarring, suggesting a safe window for removal.