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[Monoclonal antibodies in the biopsy diagnosis of tumors]
1Ustav patologickej anatómie LFUK, Bratislava.
Immunohistochemistry has made rapid advances over the last decades. The 80s have been the era of monoclonal and polyclonal antibodies which have made identification of different antigens more exact and more simple. Demonstration of individual markers of tumor cells has greatly contributed to the determination of histogenesis and to classification of tumors. The initial euphoria, however, has been on the wane as facts have accumulated demonstrating that the expression of many markers is disappearing particularly in less differentiated tumors or that new markers appear which were considered to be specific for a different type of tissue. Some of the problems involved are being dealt with in the short overview presented.
Immunohistochemistry has made rapid advances over the last decades. The 80s have been the era of monoclonal and polyclonal antibodies which have made identification of different antigens more exact and more simple. Demonstration of individual markers of tumor cells has greatly contributed to the determination of histogenesis and to classification of tumors. The initial euphoria, however, has been on the wane as facts have accumulated demonstrating that the expression of many markers is disappearing particularly in less differentiated tumors or that new markers appear which were considered to be specific for a different type of tissue. Some of the problems involved are being dealt with in the short overview presented.