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Related Concept Videos

Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

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Related Experiment Video

Updated: Jun 21, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Renal haemodynamics and function following partial portal decompression.

Sharona Ross1, Donald Thometz, Francesco Serafini

  • 1Department of Surgery, University of South Florida, c/o Tampa General Hospital, Tampa, FL 33601, USA.

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
|July 11, 2009
PubMed
Summary
This summary is machine-generated.

Partial portal decompression temporarily improves renal function in cirrhosis patients. However, these renal improvements diminish by one year post-procedure, highlighting the transient effects of shunting on kidney health.

Keywords:
Renal haemodynamicsportacaval shuntingrenal function

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Last Updated: Jun 21, 2026

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09:37

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07:10

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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

Area of Science:

  • Nephrology
  • Gastroenterology
  • Vascular Surgery

Background:

  • Portal hypertension in cirrhosis patients often leads to renal dysfunction.
  • Assessing the impact of interventions on renal hemodynamics is crucial for patient management.

Purpose of the Study:

  • To prospectively evaluate how partial portal decompression affects renal hemodynamics and function in cirrhosis patients.
  • To analyze the short-term and long-term renal outcomes following portacaval shunting or transjugular intrahepatic portosystemic shunting (TIPS).

Main Methods:

  • Fifteen cirrhosis patients underwent partial portal decompression (portacaval shunt or TIPS).
  • Renal function (serum creatinine, creatinine clearance) and renal artery Doppler ultrasound indices (RI, PI) were measured pre- and post-shunting (5 days and 1 year).
  • Portal vein-inferior vena cava pressure gradient changes were assessed.

Main Results:

  • Shunting significantly reduced portal pressure gradients and increased pulsatility index (PI) early post-procedure.
  • Creatinine clearance improved transiently in the early post-shunt period.
  • Serum creatinine levels did not significantly improve, and renal function markers tended to revert to baseline by 1 year.

Conclusions:

  • Partial portal decompression offers a temporary benefit for mild to moderate renal dysfunction in cirrhosis.
  • The positive effects on renal function following shunting are not sustained long-term, diminishing by one year post-procedure.