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Related Concept Videos

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Related Experiment Video

Updated: Jun 21, 2026

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
14:09

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

Published on: March 18, 2010

[WRN gene].

Tomohiro Katsuya1, Ryuichi Morishita

  • 1Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 14, 2009
PubMed
Summary

Werner's syndrome accelerates aging, causing early-onset cataracts and tumors. The WRN gene, encoding a DNA helicase, is crucial for genome stability and its dysfunction drives this rare genetic disorder.

Area of Science:

  • Genetics and Molecular Biology
  • Aging Research
  • Genomic Stability

Context:

  • Werner's syndrome is a rare genetic disorder exhibiting features of accelerated aging.
  • Clinical manifestations include premature cataracts, scleroderma, diabetes, and increased cancer risk.
  • The syndrome closely mimics natural aging processes but at an accelerated rate.

Purpose:

  • To review the clinical characteristics of Werner's syndrome.
  • To discuss recent research on the WRN gene and its protein product.
  • To compare Werner's syndrome with other progeroid syndromes.

Summary:

  • Werner's syndrome is caused by mutations in the WRN gene, located on chromosome 8p2-p11.2.
  • The WRN gene encodes a RecQ DNA helicase, exonuclease, and ATPase essential for maintaining genome integrity.

More Related Videos

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases
06:10

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases

Published on: December 23, 2013

Methods for Skin Wounding and Assays for Wound Responses in C. elegans
09:06

Methods for Skin Wounding and Assays for Wound Responses in C. elegans

Published on: December 3, 2014

Related Experiment Videos

Last Updated: Jun 21, 2026

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
14:09

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

Published on: March 18, 2010

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases
06:10

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases

Published on: December 23, 2013

Methods for Skin Wounding and Assays for Wound Responses in C. elegans
09:06

Methods for Skin Wounding and Assays for Wound Responses in C. elegans

Published on: December 3, 2014

  • WRN protein plays a critical role in DNA replication and telomere maintenance.

    • Impact:

    • Understanding WRN's function provides insights into DNA repair mechanisms and aging.
    • This review highlights the link between genetic defects and premature aging phenotypes.
    • Comparative analysis aids in differentiating and understanding various progeroid syndromes.